Op-brai130066 1..10
نویسندگان
چکیده
1 Hospices Civils de Lyon, Hôpital Neurologique, Neurologie C; Université Lyon I, Faculté de Médecine et de Maı̈eutique Lyon Sud Charles Mérieux, Lyon, France 2 CNRS, UMR 5229, Centre de Neurosciences Cognitives, Bron, France 3 Movement Disorder Unit, Department of Psychiatry and Neurology, CHU de Grenoble, Joseph Fourier University, 38043 Grenoble, France and INSERM, Unite 836, Grenoble Institut des Neurosciences, 38043 Grenoble, France 4 Neurosurgery Department, CHU de Grenoble, Joseph Fourier University, 38043 Grenoble, France and INSERM, Unite 836, Grenoble Institut des Neurosciences, 38043 Grenoble, France 5 Hospices Civils de Lyon, Hôpital Neurologique, Neurochirurgie A; Université Lyon I, Faculté de Médecine et de Maı̈eutique Lyon Sud Charles Mérieux, Lyon, France 6 Centre d’Investigation Clinique CHU de Grenoble, Laboratoire TIMC-IMAG, CNRS, UMR 5525, Joseph Fourier University, Grenoble F-38041, France
منابع مشابه
Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.
Osteopetrotic (op/op) mutant mice suffer from congenital osteopetrosis due to a severe deficiency of osteoclasts. Furthermore, the total number of mononuclear phagocytes is extremely low in affected mice. Serum, 11 tissues, and different cell and organ conditioned media from op/op mice were shown to be devoid of biologically active colony-stimulating factor 1 (CSF-1), whereas all of these prepa...
متن کاملOpposite Categories and Contravariant Functors
The opposite category of a category, contravariant functors and duality functors are defined. Next we state the proposition (1) the objects of C, the morphisms of C, the cod-map of C, the dom-map of C, (the composition of C),the id-map of C is a category. Let us consider C. The functor C op yielding a strict category is defined by the condition (Def. 1). (Def. 1) C op = the objects of C, the mo...
متن کاملCSF-1 deficiency in mice results in abnormal brain development.
Colony stimulating factor-1 (CSF-1) was initially identified as a growth factor for mononuclear phagocytes. This study examines the role of CSF-1 in the development of the central nervous system (CNS). CSF-1 treatment of neurons cultured from embryonic brain promoted survival and process outgrowth in a dose-dependent manner. By contrast, CSF-1 treatment of neurons cultured from the osteopetroti...
متن کاملSpleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice.
Osteoclasts are generated from monocyte/macrophage-lineage precursors in response to colony-stimulating factor 1 (CSF-1) and receptor activator of nuclear factor-κB ligand (RANKL). CSF-1-mutated CSF-1(op/op) mice as well as RANKL(-/-) mice exhibit osteopetrosis (OP) caused by osteoclast deficiency. We previously identified RANKL receptor (RANK)/CSF-1 receptor (CSF-1R) double-positive cells as o...
متن کاملDelayed hematopoietic development in osteopetrotic (op/op) mice
Changes in structure, cellularity, hematopoietic progenitor cell and macrophage content, and osteoclast activity were investigated in the hematopoietic organs of the colony-stimulating factor 1(CSF-1)-less osteopetrotic (op/op) mouse. The data indicated that op/op mice undergo an age-related hematopoietic recovery and resolution of osteopetrosis, suggesting that the hematopoietic system has the...
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